Name: Irresistible Spicy Southern Chicken Spaghetti Casserole – The Best Bold Comfort Dish
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Cuisine: Southern
Ingredients: 8 oz uncooked spaghetti; 2 cups shredded rotisserie chicken; 1 can (10.5 oz) cream of chicken soup; 1 can (10 oz) Rotel diced tomatoes with green chilies; 1 cup shredded sharp cheddar cheese; 1 cup cubed Velveeta cheese; ½ teaspoon cayenne pepper; ½ teaspoon garlic powder; ½ teaspoon onion powder; Salt & black pepper to taste; 1 tablespoon olive oil or butter (optional for greasing); Extra shredded cheese or breadcrumbs for topping (optional)

Description

This Irresistible Spicy Southern Chicken Spaghetti Casserole is the ultimate comfort food with a bold Southern twist. Loaded with rotisserie chicken, spicy Rotel tomatoes, and a creamy blend of cheddar and Velveeta, it’s perfect for family dinners, gatherings, or make-ahead meal prep. Whether you like it extra spicy or mild and cheesy, this recipe adapts to your taste buds and guarantees second servings.

Ingredients

8 oz uncooked spaghetti
2 cups shredded rotisserie chicken
1 can (10.5 oz) cream of chicken soup
1 can (10 oz) Rotel diced tomatoes with green chilies
1 cup shredded sharp cheddar cheese
1 cup cubed Velveeta cheese
½ teaspoon cayenne pepper
½ teaspoon garlic powder
½ teaspoon onion powder
Salt & black pepper to taste
1 tablespoon olive oil or butter (optional for greasing)
Extra shredded cheese or breadcrumbs for topping (optional)

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Instructions

1️⃣ Prepare the Spaghetti

• Boil spaghetti in salted water until al dente (about 7–8 minutes).
• Drain and set aside.

2️⃣ Create the Creamy Sauce

• In a large saucepan over medium heat, combine cream of chicken soup, Rotel, cheddar, Velveeta, garlic powder, onion powder, and cayenne.
• Stir constantly until cheeses melt and sauce is creamy.

3️⃣ Combine Pasta & Chicken

• Stir in shredded rotisserie chicken to the sauce mixture.
• Add cooked spaghetti and mix until well coated.

4️⃣ Assemble the Casserole

• Preheat oven to 375°F and grease a 9×13 baking dish.
• Pour the mixture into the baking dish evenly.
• Top with extra cheese or breadcrumbs if desired.

5️⃣ Bake to Perfection

• Bake uncovered for 25–30 minutes, or until bubbly and golden on top.
• Let it rest 5 minutes before serving.

Notes

For a milder version, use mild Rotel or plain diced tomatoes.
Want extra heat? Add jalapeños, red pepper flakes, or hot sauce to the sauce.
Swap cream of chicken soup with Greek yogurt or homemade béchamel for a cleaner version.
You can prepare this casserole up to 24 hours in advance, just cover and refrigerate before baking.
This dish freezes well for up to 3 months.
Serve with cornbread, a light salad, or Southern lemonade for a full meal.

Prep Time: 15 minutes
Cook Time: 30 minutes
Category: Dinner, Main Course
Method: Baking
Cuisine: Southern, American